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Table 4 Univariate and multivariate analysis of coindex of Cezanne/AFP associated with survival and recurrence in HCC patients

From: Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

Variables OS TTR
Univariate Multivariate Univariate Multivariate
P -value P -value HR 95% CI P -value P -value HR 95% CI
Gender (Female vs. Male) NS NS    NS NS   
Age, years (≤50 vs. > 50) NS NS    NS NS   
HBsAg (Negative vs. Positive) NS NS    NS NS   
GGT (U/l) (≤50 vs. > 50) 0.001 NS    0.006 NS   
Liver cirrhosis (No vs. Yes) 0.006 0.010 2.169 1.207-3.897 0.012 0.030 1.756 1.055-2.923
Tumor size (cm) (≤5 vs. > 5) <0.001 0.037 1.589 1.027-2.458 <0.001 0.007 1.785 1.175-2.710
Tumor number (Single vs. Multiple) NS NS    0.025 NS   
Satellite nodule (No vs. Yes) NS NS    0.009 NS   
Tumor capsule (No/incomplete vs. Complete) NS NS    NS NS   
Tumor differentiation (I-II vs. III-IV) NS NS    NS NS   
Vascular invasion (No vs. Yes) <0.001 <0.001 3.027 1.755-5.221 <0.001 <0.001 2.615 1.559-4.386
Coindex of Cezanne/AFP* <0.001 <0.001 0.475 0.348-0.648 <0.001 <0.001 0.515 0.389-0.681
  1. *Coindex of Cezanne/AFP was combined with Cezanne and AFP, therefore, we did not enter the Cezanne and AFP into univariate and multiple analysis with these indexes to avoid any bias in analysis.