Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues

Table 2 Mean expression fold changes of thermogenesis-related genes in adipose tissues of obese and normal-weight individuals

Gene name	Gene description	Gene Bank	Mean expression fold change				P*
Gene name	Gene description	Gene Bank	VAT-O	SAT-O	VAT-N	SAT-N	P*
ADRB1	adrenergic receptor beta 1	NM_000684	1.48	1.44	1.49	1.42	NS
ADRB2	adrenergic receptor beta 2	NM_000024	0.97	1.70	2.10	3.81	P < 0.0001
ADRB3	adrenergic receptor beta 3	NM_000025	2.62	1.66	5.43	3.15	P < 0.0001
DIO1	5’-iodothyronine deiodinase type 1	NM_000792	0.7	0.87	1.38	1.40	NS
DIO2	5’-iodothyronine deiodinase type 2	NM_001007023	0.55	1.62	2.13	2.60	P < 0.0001
THRA	thyroid hormone receptor α	NM_003250	1.79	1.70	6.03	4.18	P < 0.0001
THRB	thyroid hormone receptors β	NM_000461	0.57	0.58	1.92	1.13	P < 0.0001
UCP1	uncoupling protein 1	NM_021833	1.13	1.27	1.43	1.49	NS
UCP2	uncoupling protein 2	NM_003355	1.79	1.30	5.10	3.64	P < 0.0001
UCP3	uncoupling protein 3	NM_003356	0.82	0.53	0.85	0.86	NS

*P values calculated with the Kruskal-Wallis analysis of variance.
N: normal-weight; O: obese; VAT: visceral adipose tissue; SAT subcutaneous adipose tissue; NS: not significant.

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