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Table 7 Breadth of cellular immune responses after DNA.HTI prime and MVA.HTI boost using HTI segment-specific peptide pools

From: A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Animal Vaccine Gag Pol Vif Nef # of positive segments
p17 p24 p15 Prt RT Int
1 a 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
78 b 14 11 60 14 15 27 55 17 55 34 34 17 23 19 13
R678 DNA + +   +    + +       +    6
  MVA + + +c +    + +   +c     +    8
R679 DNA +    + +   + +   +     +    7
  MVA +    + +   + +   +     +    7
R680 DNA +    +     +      +     4
  MVA + +c   +    +d,e +      + +d,e    7
R681 DNA +    + +    + + +   +      7
  MVA +    + +   +d +   +   +   +d +d   9
  1. asegment number, S1-S16.
  2. bnumber of amino acids per segment.
  3. cnew response detectable after 1st MVA boost only.
  4. dnew response detectable after 2nd MVA boost.
  5. enew response detectable after 1st and 2nd MVA boost.
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