A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Table 7 Breadth of cellular immune responses after DNA.HTI prime and MVA.HTI boost using HTI segment-specific peptide pools

Animal	Vaccine	Gag							Pol						Vif		Nef	# of positive segments
		p17	p24					p15	Prt	RT			Int		Vif		Nef
		1 ^a	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
		78 ^b	14	11	60	14	15	27	55	17	55	34	34	17	23	19	13
R678	DNA	+	+		+			+	+						+			6
	MVA	+	+	+^c	+			+	+		+^c				+			8
R679	DNA	+			+	+		+	+		+				+			7
	MVA	+			+	+		+	+		+				+			7
R680	DNA	+			+				+					+				4
	MVA	+	+^c		+			+^d,e	+					+	+^d,e			7
R681	DNA	+			+	+			+	+	+		+					7
	MVA	+			+	+		+^d	+		+		+		+^d	+^d		9

ISSN: 1479-5876