Table 1 Transcriptomics analysis of ECs Mes by Ingenuity Pathway Analysis (IPA) revealed differential expression of over one thousand genes compared to ECs Norm
Gene name | Abbreviation | Fold change | Functional specification (IPA or GeneCards) |
|---|---|---|---|
Cell crowth & proliferation | |||
Epiregulin | EREG | +40.266 | Cell proliferation and/or angiogenesis |
Amphiregulin | AREG/AREGB | +19.911 | Growth factor & mitogen |
Baculoviral IAP | BIRC3 | +6.765 | Regulator of cell proliferation |
Repeat containing 3 | Â | Â | Â |
Budding Un- inhibited | Â | Â | Â |
By Benzimidazoles 1 | BUB1 | +6.160 | Cell cycle regulator |
NIMA-related kinase 2 | NEK2 | +5.968 | Cell cycle regulator |
Topoisomerase Iiα | TOP Iiα | +6.837 | Regulator of mitosis |
S100 calcium binding | PS100P | +6.466 | Cell proliferation stimulator |
Protein | Â | Â | Â |
Vascular growth | VEGFC | +2.266 | Endothelial cell proliferation |
Factor C | Â | Â | Â |
Human homolog of | MDM2 | +2.515 | Downstream effector of Akt signaling & enhancer of |
Mouse double minute 2 | Â | Â | endothelial cell survival |
Baculoviral IAP Repeat | BIRC5 | +3.308 | Dual role in promoting proliferation & inhibiting apoptosis |
Containing 5 | Â | Â | Â |
Insulin-like growth | IGFBP1 | +13.116 | Prolongs the half life of IGFs in cell growth promotion |
Factor Binding Protein 1 | Â | Â | Â |
Cell motility | |||
S100 calcium binding | S100A4 | +2.538 | Cell motility & invasion |
Protein A4 | Â | Â | Â |
Insulin-like growth | IGFBP1 | +13.116 | Cell migration |
Factor Binding Protein 1 | Â | Â | Â |
Transforming growth | TGFBI | +2.934 | Induced by TGFβ; has a role in inhibition of cell |
Factor beta-induced | Â | Â | adhesion |
Tetraspanin 8 | TSPAN8 | +2.461 | Regulation of cell motility |
Interleukin 6 | IL6 | +2.214 | Induction of endothelial cell motility |
Krupple-like Factor 5 | KLF5 | +3.685 | Involvement in cell movement |
Heparanase | HPSE | +2.501 | Increase endothelial cell migration |
Lectin galacroside-Binding | LGALS3 | +2.397 | Increase Endothelial cell migration |
Soluble 3 | Â | Â | Â |
Vascular development & angiogenesis | |||
Jagged1 | JAG1 | +2.311 | Cardiovascular development & angiogenesis |
Interleukin 6 | IL6 | +2.214 | Angiocrine factor |
Vascular growth factor C | VEGFC | +2.266 | Angiogenesis |
Chemokine (C-X-C Motif) | CXCR4 | +5.234 | Regulator of vascular branching & |
Receptor 4 | Â | Â | endothelial processes remodeling |
Heparanase | HPSE | +2.501 | Increase endothelial cell migration |
RUN-related Transcription | RUNX2 | +6.952 | Increase angiogenesis in endothelial cells |
Factor 2 | Â | Â | Â |
Hairy/Enhancer of | HEY1 | +2.644 | possible role in vascular development |
Split-related 1 | Â | Â | Â |