Table 1 Vemurafenib and barasertib activity evaluation in living cell lines
Cell line | BRAF status | 3 days-vemurafenib | 3 days-barasertib-HQPA |
|---|---|---|---|
IC 50 (μM) | IC 50 (nM) | ||
MBA72 | V600E | 3.2 ± 0.6 | 305 ± 4 |
Hmel-1 | V600K | 5.5 ± 0.4 | 311 ± 6 |
LND1 | wild type | 32.2 ± 1.1 | 307 ± 7 |
HBL | wild type | 37.3 ± 0.9 | 315 ± 11 |
MBA72R | V600E | 33.5 ± 0.5 | 367 ± 10 |
Hmel-1R | V600K | 25.8 ± 0.5 | 184 ± 8 |