Table 3 Association of myeloid-derived suppressor cells (MDSCs) and plasmacytoid dendritic cells (pDCs) with melanoma disease course and circulating immune markers
| Â | MDSCs | pDCs |
|---|---|---|
Melanoma activity and prognosis | Â | Â |
Systemic disease | Increased (P = 0.046) | Decreased (P = 0.001) |
Active disease | Increased (P = 0.095) | Decreased (P = 0.002) |
Death | Increased (P = 0.073) | Decreased (P = 0.009) |
Other immune markers | Â | Â |
CD3 cells | Inverse (P < 0.001) | None |
CD8 cells | Inverse (P = 0.017) | None |
PD-L1+ CD8 cells | Positive (P = 0.033) | Inverse (P = 0.044) |
Regulatory T-cells | Inverse (P = 0.007) | None |
CTLA-4 expression in Tregs | Positive (P = 0.003) | None |