From: Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients
Clinicopathological | Test set | External validation set | ||||||
---|---|---|---|---|---|---|---|---|
Features | N | Cytoplasmic | Nuclear | p | N | Cytoplasmic | Nuclear | p |
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||||
Normal | 129 | 1.29 (0.99) | 1.07 (1.29) | Â | 51 | 2.55 (0.88) | 2.64 (1.05) | Â |
OSCC | 235 | 3.04 (1.26) | 0.75 (1.03) | <0.00011 | 115 | 2.72 (1.06) | 2.18 (1.13) | 0.051 |
0.022 | 0.042 | |||||||
Age (Median, 49Â years) | Â | Â | Â | Â | Â | Â | Â | Â |
<49 | 115 | 2.97 (1.31) | 0.75 (1.02) | 0.401 | 17 | 3.12 (1.17) | 2.50 (1.17) | 0.051 |
≥49 | 120 | 3.12 (1.20) | 0.75 (1.05) | 0.862 | 98 | 2.70 (1.01) | 2.17 (1.12) | 0.222 |
Gender | Â | Â | Â | Â | Â | Â | Â | Â |
Male | 184 | 3.05 (1.26) | 0.73 (1.01) | 0.651 | 68 | 2.74 (1.03) | 2.24 (1.10) | 0.681 |
Female | 51 | 3.00 (1.26) | 0.80 (1.11) | 0.902 | 47 | 2.81 (1.06) | 2.18 (1.17) | 0.732 |
Differentiation | Â | Â | Â | Â | Â | Â | Â | Â |
WDSCC | 115 | 3.08 (1.27) | 0.81 (1.08) | Â | 28 | 2.82 (1.06) | 2.54 (1.10) | Â |
MDSCC | 113 | 2.97 (1.27) | 0.70 (0.99) | 0.461 | 70 | 2.86 (0.92) | 2.22 (1.08) | 0.281 |
PDSCC | 7 | 3.57 (0.53) | 0.57 (0.98) | 0.732 | 17 | 2.29 (1.36) | 1.68 (1.24) | 0.062 |
Clinical stage | Â | Â | Â | Â | Â | Â | Â | Â |
I | 3 | 2.67 (2.31) | 0.67 (1.15) | Â | 30 | 2.70 (1.29) | 2.32 (1.26) | Â |
II | 38 | 2.79 (1.26) | 0.79 (1.17) | Â | 21 | 2.81 (0.75) | 2.48 (1.12) | Â |
III | 69 | 3.12 (1.18) | 0.65 (0.87) | 0.361 | 21 | 2.52 (1.03) | 1.67 (0.91) | 0.601 |
IV | 125 | 3.09 (1.28) | 0.79 (1.08) | 0.942 | 43 | 2.91 (0.97) | 2.29 (1.07) | 0.092 |
Tumor stage | Â | Â | Â | Â | Â | Â | Â | Â |
I | 6 | 2.67 (1.51) | 1.17 (1.33) | Â | 48 | 2.77 (1.17) | 2.25 (1.18) | Â |
II | 69 | 2.84 (1.26) | 0.81 (1.07) | Â | 38 | 2.53 (0.95) | 2.04 (1.22) | Â |
III | 65 | 3.20 (1.19) | 0.65 (0.89) | 0.141 | 18 | 3.06 (0.80) | 2.28 (0.89) | 0.081 |
IV | 95 | 3.11 (1.28) | 0.75 (1.08) | 0.712 | 10 | 3.30 (0.67) | 2.75 (0.72) | 0.372 |
Nodal status | Â | Â | Â | Â | Â | Â | Â | Â |
N0 | 81 | 2.86 (1.43) | 0.68 (0.99) | 0.321 | 63 | 2.78 (1.04) | 2.35 (1.11) | 0.881 |
N1–4 | 154 | 3.14 (1.15) | 0.79 (1.06) | 0.462 | 52 | 2.75 (1.05) | 2.06 (1.13) | 0.212 |
Recurrence status 3 | Â | Â | Â | Â | Â | Â | Â | Â |
Non-recurrent | 82 | 2.60 (1.39) | 0.80 (1.04) | <0.011 | 47 | 2.60 (0.92) | 2.23 (1.14) | 0.051 |
Recurrent | 80 | 3.30 (1.07) | 0.89 (1.13) | 0.802 | 55 | 2.91 (1.11) | 2.16 (1.10) | 0.792 |