Figure 5

Protein expressions of inflammatory biomarkers in LV myocardium at 72 h after IR procedure. A) Protein expression of tumor necrosis factor (TNF)-α in LV myocardium. p < 0.001, * vs. other groups with different symbols (*, †, ‡). B) Protein expression of nuclear factor (NF)-κB in LV myocardium. p < 0.001, * vs. other groups with different symbols (*, †, ‡). C) Protein expression of matrix metalloproteinase (MMP)-9 in LV myocardium. p < 0.001, * vs. other groups with different symbols (*, †, ‡). D) Protein expression of intercellular adhesion molecule (ICAM)-1. p < 0.001, * vs. other groups with different symbols (*, †, ‡). All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 8). Symbols (*, †, ‡) indicate significance (at 0.05 level). WT-SC = wide type sham control; WT-IR = wide type + ischemia reperfusion (IR); DDP4^D-SC = dipeptidyl peptidase-IV (DPP4) deficiency sham control; DDP4^D-IR = DDP4^D + IR; WT-IR-Sita = wide type + IR + sitagliptin.