Table 3 Gene expression changes in DV infection
From: Overcoming tumor immune evasion with an unique arbovirus
Gene | Symbol | Function | Fold-increase during DV Infection | Immunotherapy significance |
|---|---|---|---|---|
IL-1beta | IL-1β | Inflammation | 9.80 [52] | Fever, Vascular permeability [35] |
Interleukin-2 | IL-2 | T cell growth | 3.97 [46] | CTL growth, NK Activation [80] |
Interleukin-12 | CLMF/CLMF2 | Shift to TH1 Cytokines | 2.20 [46] | TH1 cytokine storm [55] |
Interferon γ | IFNG | Up-regulate Class I MHC | 2.85 [46] | CTL recognize HLA + peptide [11] |
CD8 antigen | CD8β1 | CTL Co-receptor | 5.74 [52] | Stabilizes MHC-TCR bond [68] |
Inducible T cell co-stimulatory ligand | ICOSLG | Non-naïve T cell activation TH1 cytokines | 2.44 [52] | Optimize response of CTL [25] |
Chemokine ligand 3 | CCL3 | T-cell activation Autoimmunity | 4.64 [52] | Marker of vaccine response [25] |
Chemokine ligand 5 | CCL5 | T-cell localization | 7.33 [52] | T-cell attraction to tumor area [81] |
TRAIL | TRAIL | Apoptosis Induction | 42.0 [65] | Induces Apoptosis in Tumor Cells [82] |
Interferon-protein-10 | IP10 | T cell activation, Localization | 46.0 [65] | Levels correlate w/clinical outcome in RCC [71] |
Granulysin | GNLY | Apoptosis Induction | 4.90 [52] | Induces Apoptosis [52] |
Granzyme A | GZMA | Target cell lysis | 4.61 [52] | Effector CTL [25] |
MHC class II DRα | HLA-DRA | Antigen Presentation | 7.26 [52] | Antigen Presentation [52] |
MHC class II DPα1 | HLA-DPα1 | MHC peptide Display | 4.58 [52] | Antigen (Ag) Presentation [52] |
MHC class I DPβ1 | HLA-DPβ1 | MHC peptide Display | 2.72 [52] | Antigen Presentation [52] |
ζ chain kinase | ZAP70 | TCR signal transduction | 3.03 [52] | Restores CTL signaling [52] |