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Table 3 Gene expression changes in DV infection

From: Overcoming tumor immune evasion with an unique arbovirus

Gene Symbol Function Fold-increase during DV Infection Immunotherapy significance
IL-1beta IL-1β Inflammation 9.80 [52] Fever, Vascular permeability [35]
Interleukin-2 IL-2 T cell growth 3.97 [46] CTL growth, NK Activation [80]
Interleukin-12 CLMF/CLMF2 Shift to TH1 Cytokines 2.20 [46] TH1 cytokine storm [55]
Interferon γ IFNG Up-regulate Class I MHC 2.85 [46] CTL recognize HLA + peptide [11]
CD8 antigen CD8β1 CTL Co-receptor 5.74 [52] Stabilizes MHC-TCR bond [68]
Inducible T cell co-stimulatory ligand ICOSLG Non-naïve T cell activation TH1 cytokines 2.44 [52] Optimize response of CTL [25]
Chemokine ligand 3 CCL3 T-cell activation Autoimmunity 4.64 [52] Marker of vaccine response [25]
Chemokine ligand 5 CCL5 T-cell localization 7.33 [52] T-cell attraction to tumor area [81]
TRAIL TRAIL Apoptosis Induction 42.0 [65] Induces Apoptosis in Tumor Cells [82]
Interferon-protein-10 IP10 T cell activation, Localization 46.0 [65] Levels correlate w/clinical outcome in RCC [71]
Granulysin GNLY Apoptosis Induction 4.90 [52] Induces Apoptosis [52]
Granzyme A GZMA Target cell lysis 4.61 [52] Effector CTL [25]
MHC class II DRα HLA-DRA Antigen Presentation 7.26 [52] Antigen Presentation [52]
MHC class II DPα1 HLA-DPα1 MHC peptide Display 4.58 [52] Antigen (Ag) Presentation [52]
MHC class I DPβ1 HLA-DPβ1 MHC peptide Display 2.72 [52] Antigen Presentation [52]
ζ chain kinase ZAP70 TCR signal transduction 3.03 [52] Restores CTL signaling [52]