Figure 3

Foxp3 ⁺ T _regs in the primary tumor increases with higher melanoma MMP-23 expression. (A) Heterogeneous nuclear positivity for Foxp3 in TILs from a primary melanoma with a high MMP-23 composite score and 100 Foxp3⁺ T_regs/high-power field. (C) Nuclear reactivity for Foxp3 limited to a few TILs (5 Foxp3⁺ T_regs/high-power field) (arrow) from a primary melanoma with no MMP-23 expression (200X). (B, D) Corresponding consecutive MMP-23-stained sections of A and C, respectively.