Figure 3From: Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects Effect of LCI699 and eplerenone on adrenal hormones, serum electrolytes, cardiac and renal parameters in dTG rats. (A) Plasma aldosterone concentrations (PAC); (B) urinary aldosterone excretion (UAldoE); (C) serum potassium; (D) serum sodium; (E) mean arterial pressure (MAP); (F) LV fractional shortening (FS); (G) LV isovolumic relaxation time (IVRT) as a percentage of R-R interval; (H) LV myocardial cell size; (I) 24-h urine volume (V); (J) 24-h urinary albumin excretion (UAE); (K) blood urea nitrogen (BUN) and (L) creatinine clearance (CCr). Values are shown for double-transgenic (dTG) rats (triangle), dTG rats treated with LCI699 (3, 10, 30 or 100 mg/kg/day in drinking water) or eplerenone (Epl, 30 mg/kg/day in chow) from 3 to 7 weeks of age (square) and in control Sprague-Dawley (S-D) rats (circle). Eplerenone vehicle controls are depicted separately from LCI699 vehicle controls. Measurements were taken at 7 weeks of age. Values are mean ± SEM. Number of evaluable animals was n = 6 per dose group, with the exception of S-D rat controls (n = 11). *P < 0.05 vs dTG rats. † P < 0.05 vs S-D rats.Back to article page