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Table 2 The effects of BBR and its derivatives on weight and lipid profiles

From: Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice

  Weight (g) TG (mmol/L) TC (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L)
Control 34.2 ± 0.5 5 ± 1.1 22.9 ± 1.5 1.6 ± 0.25 5.9 ± 1.12
BBR 33.4 ± 0.7 3.9 ± 0.8 17.3 ± 2.1* 1.7 ± 0.31 4.8 ± 1.2*
dhBBR 32.1 ± 1.2 4.2 ± 0.7 21.6 ± 1.8 1.6 ± 0.29 5.1 ± 1.3*
Di-MeBBR 33.6 ± 1.7 4.4 ± 0.9 18.9 ± 1.3* 1.8 ± 0.32 4.5 ± 0.9*
  1. Data are shown as means ± SD. *P <0.05 vs. control. TG, total triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BBR, berberine; dhBBR, dihdroberberine; Di-MeBBR, 8,8-dimethyldihydroberberine.