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Table 2 The effects of BBR and its derivatives on weight and lipid profiles

From: Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice

 

Weight (g)

TG (mmol/L)

TC (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

Control

34.2 ± 0.5

5 ± 1.1

22.9 ± 1.5

1.6 ± 0.25

5.9 ± 1.12

BBR

33.4 ± 0.7

3.9 ± 0.8

17.3 ± 2.1*

1.7 ± 0.31

4.8 ± 1.2*

dhBBR

32.1 ± 1.2

4.2 ± 0.7

21.6 ± 1.8

1.6 ± 0.29

5.1 ± 1.3*

Di-MeBBR

33.6 ± 1.7

4.4 ± 0.9

18.9 ± 1.3*

1.8 ± 0.32

4.5 ± 0.9*

  1. Data are shown as means ± SD. *P <0.05 vs. control. TG, total triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BBR, berberine; dhBBR, dihdroberberine; Di-MeBBR, 8,8-dimethyldihydroberberine.