Figure 7
From: Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice
Effects of berberine and its derivatives on gene expression of inflammatory mediators in atherosclerotic plaques. ApoE−/− mice were fed with the Western diet for 16 weeks and then treated with BBR or its derivatives (dhBBR and Di-MeBBR) for 16 weeks. Real-time PCR was performed to determined mRNA expression of CD68 (A), EMMPRIN (B), NFkB p65 (C), MMP-9 (D), ICAM-1 (E), VCAM-1 (F) in the aorta. *P < 0.05 vs. the control group.