FA effects against in vivo cardiac LAD ischaemia-reperfusion in pentobarbital-anaesthetised rats. FA treatment during ischaemia reduced infarction in young, but not in old or Zucker obese animals. (A-F): Area at risk as percentage of left ventricle and Infarct size as percentage of area at risk (AAR) for young (A, D), old (B, E) and Zucker obese (C, F) rats; (G-I): Mean arterial pressure (MAP) at baseline and end rperfusion for young (G), old (H) and Zucker obese (I) rats; (J-L): Heart rate (HR) at baseline and end reperfusion for young (J), old (K) and Zucker obese (L) rats. (n = 6-10 animals per group). Mean ± SEM, *P < 0.05 vs. FA = 0 group for infarct size; † P < 0.05 baseline value vs reperfusion value for control group; *P < 0.05 for interaction effect (experimental time effect (baseline minus reperfusion) for control vs. that for FA treated group. Mean ± SEM.