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Table 3 Univariate and multivariate analysis for overall survival in CRC tissue microarray

From: Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer

Variable Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P Hazard ratio (95% CI) P
Sex     
Female 1 0.950   
Male 1.013 (0.670-1.533)    
Age     
≤60 1 0.222   
>60 1.294 (0.855-1.958)    
Tumor location     
Colon 1 0.061   
Rectal 1.502 (0.982-2.298)    
Differentiation     
Well + Moderate 1 <0.001 1 0.016
Poorly 2.736 (1.593-4.699)   1.945 (1.132-3.340)  
Preoperative CEA level     
< 5 ng/ml 1 <0.001 1 0.022
≥ 5 ng/ml 2.480 (1.590-3.866)   1.741 (1.084-2.797)  
Preoperative CA19-9 level     
< 37 U/ml 1 <0.001 1 0.014
≥37 U/ml 2.553 (1.614-4.038)   1.825 (1.127-2.954)  
pT     
T1 + T2 1 0.169   
T3 + T4 1.532 (0.834-2.813)    
pN     
N0 1 <0.001   
N1-2 2.438 (1.609-3.696)    
pM     
M0 1 <0.001   
M1 7.502 (4.701-11.971)    
TNM stage     
I + II 1 <0.001 1 0.006
III + IV 2.460 (1.618-3.741)   1.933 (1.210-3.089)  
RFC4 expression     
Normal 1 0.011 1 0.366
High 1.745 (1.136-2.680)   1.246 (0.774-2.005)