Table 3 Univariate and multivariate analysis for overall survival in CRC tissue microarray

Sex

Female

1

0.950

Male

1.013 (0.670-1.533)

Age

≤60

1

0.222

>60

1.294 (0.855-1.958)

Tumor location

Colon

1

0.061

Rectal

1.502 (0.982-2.298)

Differentiation

Well + Moderate

1

<0.001

1

0.016

Poorly

2.736 (1.593-4.699)

1.945 (1.132-3.340)

Preoperative CEA level

< 5 ng/ml

1

<0.001

1

0.022

≥ 5 ng/ml

2.480 (1.590-3.866)

1.741 (1.084-2.797)

Preoperative CA19-9 level

< 37 U/ml

1

<0.001

1

0.014

≥37 U/ml

2.553 (1.614-4.038)

1.825 (1.127-2.954)

pT

T1 + T2

1

0.169

T3 + T4

1.532 (0.834-2.813)

pN

N0

1

<0.001

N1-2

2.438 (1.609-3.696)

pM

M0

1

<0.001

M1

7.502 (4.701-11.971)

TNM stage

I + II

1

<0.001

1

0.006

III + IV

2.460 (1.618-3.741)

1.933 (1.210-3.089)

RFC4 expression

Normal

1

0.011

1

0.366

High

1.745 (1.136-2.680)

1.246 (0.774-2.005)