Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol

Table 2 Trial schedule

Protocol treatments and assessments		Pre-enrollment	Week 4	Week8	Week 12	Week 16	Week 20	Week 24	Mastectomy
Protocol treatments	Letrozole
Protocol treatments	Zoledronic acid		↓
Demographics, current medications, dental examination		○
Physical examination		○	○¹
Complete blood count, blood biochemical test, bone metabolism markers		○	○²	○		○		○
Enhanced MRI, tumor markers		○			○			○
Palpation, ultrasound examination		○	○	○	○	○	○	○
Vδ1+ T cells and Vδ2+ T cells in peripheral blood ³			○	○				○
IFN- γ ⁴			○
Pathological examination⁵		○		○					○
PEPI score									○

¹Body temperature before and 4–6 hours after the administration of zoledronic acid.
²Bone metabolism markers that are expected.
³The frequency of Vδ1+ T cells and Vδ2+ T cells among CD3+ T cells in peripheral blood.
⁴IFN-γ at 4–6 hours after the administration of zoledronic acid.
⁵ER, PgR, Ki67.

ISSN: 1479-5876