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Table 2 Trial schedule

From: Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol

Protocol treatments and assessments Pre-enrollment Week 1 Week 4 Week8 Week 12 Week 16 Week 20 Week 24 Mastectomy
Protocol treatments Letrozole  
Zoledronic acid        
Demographics, current medications, dental examination         
Physical examination   1       
Complete blood count, blood biochemical test, bone metabolism markers   2      
Enhanced MRI, tumor markers         
Palpation, ultrasound examination    
Vδ1+ T cells and Vδ2+ T cells in peripheral blood 3         
IFN- γ 4          
Pathological examination5        
PEPI score         
  1. 1Body temperature before and 4–6 hours after the administration of zoledronic acid.
  2. 2Bone metabolism markers that are expected.
  3. 3The frequency of Vδ1+ T cells and Vδ2+ T cells among CD3+ T cells in peripheral blood.
  4. 4IFN-γ at 4–6 hours after the administration of zoledronic acid.
  5. 5ER, PgR, Ki67.