Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

Table 3 Correlations analysis between activated caspase-9, activated caspase-10, pIRF7, virus infection markers, and systemic lupus erythematosus disease activity

		SLEDAI	activated caspase 9	activated caspase 10	pIRF7	activated MAVS	MDA5
SLEDAI	r	1.00	-0.47^*	-0.31	-0.31	-0.36^*	-0.03
SLEDAI	p	X	0.01^*	0.13	0.09	<0.05^*	0.90
activated caspase 9	r		1.00	0.81^*	0.83^*	0.88^*	0.39
activated caspase 9	p		X	<0.01^*	<0.01^*	<0.01^*	0.06
activated caspase 10	r			1.00	0.91^*	0.85^*	0.23
activated caspase 10	p			X	<0.01^*	<0.01^*	0.33
pIRF7	r				1.00	0.84^*	0.14
pIRF7	p				X	<0.01^*	0.51
activated MAVS	r					1.00	0.27
activated MAVS	p					X	0.21
MDA5	r						1.00
MDA5	p						X

Abbreviations: r, correlation coefficient; p, p value; SLEDAI, Systemic lupus erythematosus disease activity index 2000; pIRF7, phosphorylated interferon regulator factor 7; MAVS, mitochondrial antiviral signaling protein; MDA5, Melanoma Differentiation-Associated protein 5.
*p < 0.05.

ISSN: 1479-5876