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Table 1 Demographic data of SLE patients and healthy controls

From: Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

 

Healthy controls (n = 18)

SLE patients (n = 35)

Disease control (n = 15)

p value

Age (y) (mean ± SD)

43.78 ± 10.90

40.24 ± 11.78

47.53 ± 11.06

0.17

Male/female

5/13

3/32

1/13

0.92

Peripheral blood studies

    

Leukocytes (×1000/ml)

5.85 ± 2.15

6.35 ± 2.61

7.92 ± 3.11

0.12

% granulocyte

61.60 ± 12.76

67.89 ± 12.63

72.36 ± 16.25

0.25

% lymphocyte

31.01 ± 10.85

23.65 ± 10.87

20.46 ± 14.77

0.18

% monocyte

5.63 ± 1.74

6.14 ± 2.71

4.63 ± 2.10

0.48

Hemoglobin (mg/dL)

13.32 ± 1.77

11.73 ± 1.73

12.52 ± 1.58

<0.01*

Platelet counts (×10000/ml)

23.19 ± 6.82

22.19 ± 8.91

23.05 ± 8.60

0.93

c3 level (median, IQR)

ND

91.0 (61.4, 107.5)

ND

 

c4 Level (median, IQR)

ND

19.30 (9.2, 24.)

ND

 

a-dsDNA (median, IQR)

ND

13.4 (1.78, 67)

ND

 

a-rib p (median, IQR)

ND

0.10 (0.1, 18)

ND

 

SLEDAI score ( median, IQR)

ND

6 (4,12)

ND

 

Medication used during at blood test

    

Equivalent prednisolone dose per day (mg)

 

0 (0,8.75)

0 (0,8.75)

0.90

Immune modulators except steroid (number)

 

1 (1,1)

1 (1, 1.25)

0.48

Leukocyte Apoptosis by flow cytometry

    

Leukocyte apoptosis (%)

    

Annexin V (%)

10.7 (8.9, 13.8)

11.9 (8.6, 17.1)

12.1 (9.3, 20.6)

0.41

APO2.7 (%)

0.7 (0.5, 0.9)

1.3 (0.9, 2.0)

1.17 (0.9, 2.1)

<0.01*

Annexin V + 7AAD (%)

3.34 (2.85, 4.78)

6.34 (3.7, 9.7)

7.06 (5.16, 13.95)

<0.01*

Neutrophil apoptosis (%)

    

Annexin V (%)

14.5 (10.0, 16.7)

19.4 (11.5, 29.8)

18.9 (14.4, 28.5)

0.08

APO2.7 (%)

0.51 (0.39, 0.62)

0.57 (0.41, 1.6)

0.82 (0.35, 1.39)

0.18

Annexin V + 7AAD (%)

3.7 (2.1, 7.6)

8.6 (2.7, 19.2)

15.94 (10.9, 31.4)

<0.01*

Lymphocyte apoptosis (%)

    

Annexin V (%)

4.85 (4.01, 7.26)

6.28 (4.18, 9.52)

6.97 (4.00, 12.47)

0.16

APO2.7 (%)

0.34 (0.22, 0.45)

0.67 (0.4, 0.8)

0.79 (0.60, 1.01)

<0.01*

Annexin V + 7AAD (%)

1.76 (1.17, 2.40)

2.12 (1.31, 2.87)

2.20 (1.22, 3.54)

0.49

Monocyte apoptosis (%)

    

Annexin V (%)

16.7 (13.0, 21.8)

16.4 (10.9, 22.1)

18.2(14.0, 23.9)

0.65

APO2.7 (%)

1.7 (1.05, 2.44)

2.8 (1.9, 5.2)

2.3 (1.3, 4.6)

0.02*

Annexin V + 7AAD (%)

5.5 (4.2, 6.6)

8.0 (4.3, 14.4)

8.2 (4.5, 17.0)

0.07

  1. Abbreviations: SLE, systemic lupus erythematosus; IQR, inter-quartile range.
  2. Data presented with median (IQR) or mean ± SD.
  3. Continuous variables among three groups were compared using one-way ANOVA (analysis of variance) between healthy group, SLE, and diseases control.
  4. Comparison between the three groups with non-normalized distributed parameters was calculated using the Kruskal-Wallis test, while post-hoc analysis was by Mann-Whitney U test.
  5. *p < 0.05.
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Journal of Translational Medicine

ISSN: 1479-5876

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