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Table 1 Demographic data of SLE patients and healthy controls

From: Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

  Healthy controls (n = 18) SLE patients (n = 35) Disease control (n = 15) p value
Age (y) (mean ± SD) 43.78 ± 10.90 40.24 ± 11.78 47.53 ± 11.06 0.17
Male/female 5/13 3/32 1/13 0.92
Peripheral blood studies     
Leukocytes (×1000/ml) 5.85 ± 2.15 6.35 ± 2.61 7.92 ± 3.11 0.12
% granulocyte 61.60 ± 12.76 67.89 ± 12.63 72.36 ± 16.25 0.25
% lymphocyte 31.01 ± 10.85 23.65 ± 10.87 20.46 ± 14.77 0.18
% monocyte 5.63 ± 1.74 6.14 ± 2.71 4.63 ± 2.10 0.48
Hemoglobin (mg/dL) 13.32 ± 1.77 11.73 ± 1.73 12.52 ± 1.58 <0.01*
Platelet counts (×10000/ml) 23.19 ± 6.82 22.19 ± 8.91 23.05 ± 8.60 0.93
c3 level (median, IQR) ND 91.0 (61.4, 107.5) ND  
c4 Level (median, IQR) ND 19.30 (9.2, 24.) ND  
a-dsDNA (median, IQR) ND 13.4 (1.78, 67) ND  
a-rib p (median, IQR) ND 0.10 (0.1, 18) ND  
SLEDAI score ( median, IQR) ND 6 (4,12) ND  
Medication used during at blood test     
Equivalent prednisolone dose per day (mg)   0 (0,8.75) 0 (0,8.75) 0.90
Immune modulators except steroid (number)   1 (1,1) 1 (1, 1.25) 0.48
Leukocyte Apoptosis by flow cytometry     
Leukocyte apoptosis (%)     
Annexin V (%) 10.7 (8.9, 13.8) 11.9 (8.6, 17.1) 12.1 (9.3, 20.6) 0.41
APO2.7 (%) 0.7 (0.5, 0.9) 1.3 (0.9, 2.0) 1.17 (0.9, 2.1) <0.01*
Annexin V + 7AAD (%) 3.34 (2.85, 4.78) 6.34 (3.7, 9.7) 7.06 (5.16, 13.95) <0.01*
Neutrophil apoptosis (%)     
Annexin V (%) 14.5 (10.0, 16.7) 19.4 (11.5, 29.8) 18.9 (14.4, 28.5) 0.08
APO2.7 (%) 0.51 (0.39, 0.62) 0.57 (0.41, 1.6) 0.82 (0.35, 1.39) 0.18
Annexin V + 7AAD (%) 3.7 (2.1, 7.6) 8.6 (2.7, 19.2) 15.94 (10.9, 31.4) <0.01*
Lymphocyte apoptosis (%)     
Annexin V (%) 4.85 (4.01, 7.26) 6.28 (4.18, 9.52) 6.97 (4.00, 12.47) 0.16
APO2.7 (%) 0.34 (0.22, 0.45) 0.67 (0.4, 0.8) 0.79 (0.60, 1.01) <0.01*
Annexin V + 7AAD (%) 1.76 (1.17, 2.40) 2.12 (1.31, 2.87) 2.20 (1.22, 3.54) 0.49
Monocyte apoptosis (%)     
Annexin V (%) 16.7 (13.0, 21.8) 16.4 (10.9, 22.1) 18.2(14.0, 23.9) 0.65
APO2.7 (%) 1.7 (1.05, 2.44) 2.8 (1.9, 5.2) 2.3 (1.3, 4.6) 0.02*
Annexin V + 7AAD (%) 5.5 (4.2, 6.6) 8.0 (4.3, 14.4) 8.2 (4.5, 17.0) 0.07
  1. Abbreviations: SLE, systemic lupus erythematosus; IQR, inter-quartile range.
  2. Data presented with median (IQR) or mean ± SD.
  3. Continuous variables among three groups were compared using one-way ANOVA (analysis of variance) between healthy group, SLE, and diseases control.
  4. Comparison between the three groups with non-normalized distributed parameters was calculated using the Kruskal-Wallis test, while post-hoc analysis was by Mann-Whitney U test.
  5. *p < 0.05.