Skip to main content

Advertisement

Table 1 Left ventricular function and hemodynamics in MR: effect of VNS

From: Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation

Measurement Arm Baseline 3 month 6 month
HR (beats/min) Control 103 ± 6 135 ± 9 139 ± 11
  VNS 106 ± 6 137 ± 10 122 ± 7*
mAoP (mm Hg) Control 99 ± 5 85 ± 8 80 ± 8
  VNS 97 ± 5 86 ± 9 78 ± 9
PCWP (mm Hg) Control 5.9 ± 0.4 17.4 ± 1.4 19.1 ± 1.9
  VNS 5.7 ± 0.5 18.6 ± 1.6 13.2 ± 1.7*
dp/dtmax (mm Hg/s) Control 2543 ± 226 1925 ± 255 1782 ± 278
  VNS 2496 ± 209 1911 ± 243 1938 ± 295
RF (%) Control 58 ± 3 63 ± 4 61 ± 5
  VNS 59 ± 3 65 ± 4 61 ± 6
LVEDD (cm) Control 3.5 ± 0.2 4.9 ± 0.3 5.8 ± 0.3
  VNS 3.4 ± 0.2 4.8 ± 0.3 6.1 ± 0.4
LVESD (cm) Control 1.9 ± 0.1 2.6 ± 0.1 3.1 ± 0.3
  VNS 1.8 ± 0.1 2.5 ± 0.1 3.2 ± 0.3
LVEDV (ml) Control 43 ± 4 84 ± 10 110 ± 12
  VNS 42 ± 4 85 ± 10 117 ± 13
LVESV (ml) Control 19 ± 3 30 ± 8 41 ± 10
  VNS 18 ± 3 28 ± 8 42 ± 11
LV mass/BW (g/kg) Control 3.8 ± 0.2 5.5 ± 0.3 5.8 ± 0.3
  VNS 3.7 ± 0.2 5.4 ± 0.3 6.3 ± 0.3*
  1. Values presented as mean ± SEM. *P < 0.05 compared with the control.
  2. HR = heart rate; mAoP = mean aortic pressure; PWCP = Pulmonary capillary wedge pressure; RF = regurgitant fraction; LV = left ventricle/ventricular; EDD = end-diastolic dimension; EDV = end- diastolic volume; ESD = end-systolic dimension; ESV = end-systolic volume; BW = body weight.