Figure 3
The diagnostic performance of the copy number ratio-based techniques and DIPS. A. Diagnostic performance of the three techniques, i.e., DIPS, the E2/E6E7 ratio analysis and the E1-L1/E6E7 ratio analysis, on the different grades of cervical precancerous/cancerous lesions. Ca, invasive cancer. B. Schematic representation of the detection ranges of the two copy-number-based techniques and DIPS and their relationships with the population of cervical lesions. C. Box plots indicating the viral load distribution characteristics among women with different levels of cervical lesions. D. The distribution characteristics of false-positive cases and false-negative cases that were detected by the E2/E6E7 ratio analysis and the E1-L1/E6E7 ratio analysis are shown, together with their corresponding viral loads. * and #, The differences between the numbers of false-negative cases between the five grades of cervical lesions were of statistical significance, p < 0.001, two-sided χ2 test. ** and ##, The differences between the numbers of false-negative cases between three viral load tertiles were of statistical significance, p < 0.001, two-sided χ2 test. Ca, invasive cancer. E. Predictive performance of the three techniques on the cervical precancerous/cancerous lesions during the three rounds of cervical biopsies.