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Figure 5 | Journal of Translational Medicine

Figure 5

From: AAV2/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis, in LDLR-KO mice on high cholesterol diet

Figure 5

Immune response status of aortas is Th2. A. shows a QRT-PCR analysis of IL-4 expression, a Th2 response cytokine. Note that IL-4 levels were significantly higher (p <0.05) in hSMAD3-treated animals than Neo-treated. B. shows a QRT-PCR analysis of IL-10 expression, another Th2 response cytokine. Note, again, IL-10 levels trended higher in hSMAD3-treated animals than Neo-treated. C. shows a QRT-PCR analysis of IL-7 expression, a Th1 response cytokine. Note that IL-7 levels were higher (p <0.05) in hSMAD3-treated animals than Neo-treated, however, overall, the changes were very minor. D. shows a QRT-PCR analysis of IL-12 expression, another Th1 response cytokine. Note IL-12 levels trended lower in hSMAD3-treated animals than Neo-treated.

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Journal of Translational Medicine

ISSN: 1479-5876

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