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Table 2 Stroke patients: correlations between biochemical markers, stroke severity, volume of infarct and stroke outcome

From: Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

Values of spearman rho correlations: IL-6 TNF-α Glutamate
IL-6 IL-6 TNF-α TNF-α Glu Glu
<12 h 72 h <12 h 72 h <12 h 72 h
Clinical severity (APACHE II) All patients 0.261 0.326** 0,130 0,155 −0.076 −0.029
−0.061 0.484** −0,085 0,068 0.421* −0.193
Large infarcts 0.630*** 0.433 0.244 0.347 −0.052 0.149
−0.369 0.197 −0,821 −0,462 −0.350 −0.727**
Medium infarcts −0.066 0.241 0.190 0.044 −0.042 −0.007
0.261 0.759** - 0.400 0.374 0.410
Stroke severity (NIHSS) All patients 0.068 0.497*** 0.312 0.247 0.193 0.261*
- - −0.488 −0.488 - -
Large infarcts 0.247 0.020 0.388 0.433 0.165 −0.013
- - −0.866 −0.866 - -
Medium infarcts −0.223 0.505*** −0.023 −0.108 0.217 0.371**
- - −0.866 −0.866 - -
Volume of infarct§ All patients 0.207 0.290** 0.476** 0.275 0.120 0.151
Large infarcts 0.398 0.299 0.592* 0364 0.325 0.324
Medium infarcts 0.069 −0.113 0.097 0.178 0.001 0.001
Clinical outcome: 3-months mRS All patients 0.230 0.444*** 0.352* 0.150 0.101 0.006
- - 0.546 −0.095 - -
Large infarcts 0.453* 0.455 0.370 0.283 0.235 0.295
- - 0.105 0.316 - -
Medium infarcts 0.042 0.273 0.338 0.120 −0.023 −0.080
- - 0.316 −0.738 - -
Clinical outcome: 3-months Barthel index All patients −0.121 −0.245 −0.152 −0.109 −0.164 −0.017
−0.492* −0.303 −0.536 −0.009 0.092 0.433*
Large infarcts −0.366 −0.366 0.119 −0.444 −0.268 0.000
−0.449 −0.338 −0.200 −0.300 −0.570 0.591*
Medium infarcts −0.053 −0.078 −0.262 0.168 −0.042 0.006
−0.702* 0.025 −0.316 0.738 0.368 −0.495
  1. The numbers in the upper line of each row correspond to stroke patients and the line below to controls.
  2. *P < 0.1; **P < 0.05; ***P < 0.01. Results with P < 0.1 are in bold
  3. §Only stroke patients
  4. APACHE II, Acute Physiology and Chronic Health Evaluation II scale; NIHSS, National Institutes of Health Stroke Scale.