Figure 3
From: HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
A schematic depicting the formation of a Virological Synapse (VS) upon engagement of α 4 β 7 by HIV-1 envelope. An HIV-1 infected cell encounters a highly susceptible target cell expressing high levels of α4β7 (panel a). HIV-1 envelope on the surface of the infected cell binds to α4β7 on the target cell and activates the downstream integrin LFA-1 (panel b). LFA-1 binds to its ligand ICAM-1 (panel c) and stabilizes a VS.