Figure 1

On gut α ₄ β ₇ ^high CD4⁺ T cells α ₄ β ₇ colocalizes with CD4 and CCR5. Freshly isolated gut cells obtained from biopsies taken from healthy donors were stained with the α₄β₇ mAb Act-1 (red), the CD4 mAb OKT4 (purple), and the CCR5 mAb 2D7 (green) and viewed under a confocal microscope. Unstained and individual stains of a representative cell are presented along with digitally defined regions of colocalization between α₄β₇ and CD4 (yellow) and α₄β₇, CD4 and CCR5 (blue). This cell is representative of greater that 60 cells analyzed from four donors.