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Table 1 Effect of genetic polymorphisms of HIV-1 receptors and ligands on HIV-1 mother–to-child transmission and pediatric disease progression.

From: HIV-1 co-receptor usage:influence on mother-to-child transmission and pediatric infection

Gene Polymorphism Influence on Ref.
   MTCT risk Disease progression  
CCR5 delta32 Decreased Delayed 53,63
CCR5 59029A Augmented Accelerated 62
CCR2 64I Contradicting results Delayed 63-65
CX3CR1 I249 No effect Accelerated 67
CD4 C868T Augmented, when heterozygously expressed in the children unknown 69
DC-SIGN p-336C and p-201A Augmented, when expressed in the children unknown 70
DC-SIGN exon 4 : R198Q, E214D, R221Q, and L242V Augmented, when expressed in the children unknown 70
DC-SIGNR H1 and H3 Augmented unknown 71
CCL3 Copy number variation Augmented, when present in the children unknown 72
SDF-1 3’UTR 801A Augmented, when present in the mother Accelerated 62, 73-76