HIV-1 co-receptor usage:influence on mother-to-child transmission and pediatric infection

Table 1 Effect of genetic polymorphisms of HIV-1 receptors and ligands on HIV-1 mother–to-child transmission and pediatric disease progression.

Gene	Polymorphism	Influence on		Ref.
		MTCT risk	Disease progression
CCR5	delta32	Decreased	Delayed	53,63
CCR5	59029A	Augmented	Accelerated	62
CCR2	64I	Contradicting results	Delayed	63-65
CX3CR1	I249	No effect	Accelerated	67
CD4	C868T	Augmented, when heterozygously expressed in the children	unknown	69
DC-SIGN	p-336C and p-201A	Augmented, when expressed in the children	unknown	70
DC-SIGN	exon 4 : R198Q, E214D, R221Q, and L242V	Augmented, when expressed in the children	unknown	70
DC-SIGNR	H1 and H3	Augmented	unknown	71
CCL3	Copy number variation	Augmented, when present in the children	unknown	72
SDF-1	3’UTR 801A	Augmented, when present in the mother	Accelerated	62, 73-76

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