Table 5 Sensitivity and specificity of individual markers or their combination in predicting response to treatment
|  | AUC | Cut-off ≥ | Sensitivity (%) | Specificity (%) | Overall accuracy (%) |
|---|---|---|---|---|---|
MGMT | 0.73 | 0.72 | 78.9 | 77.8 | 78.5 |
XPD | 0.70 | 0.22 | 89.4 | 44.4 | 75.0 |
BRCA1 | 0.62 | 2.43 | 63.1 | 66.6 | 64.3 |
ERCC1 | 0.56 | 1.37 | 73.7 | 44.4 | 64.3 |
GSTP1 | 0.57 | 1.09 | 63.1 | 55.5 | 60.7 |
MGMT + XPD | 0.67 | - | 63.1 | 55.5 | 60.7 |
XPD + ERCC1 | 0.69 | - | 73.9 | 44.4 | 67.8 |
XPD + GSTP1 | 0.69 | - | 78.9 | 44.4 | 67.8 |
Five markers together | 0.79 | - | 74.0 | 77.8 | 75.0 |