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Table 5 Sensitivity and specificity of individual markers or their combination in predicting response to treatment

From: Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy

  AUC Cut-off ≥ Sensitivity (%) Specificity (%) Overall accuracy (%)
MGMT 0.73 0.72 78.9 77.8 78.5
XPD 0.70 0.22 89.4 44.4 75.0
BRCA1 0.62 2.43 63.1 66.6 64.3
ERCC1 0.56 1.37 73.7 44.4 64.3
GSTP1 0.57 1.09 63.1 55.5 60.7
MGMT + XPD 0.67 - 63.1 55.5 60.7
XPD + ERCC1 0.69 - 73.9 44.4 67.8
XPD + GSTP1 0.69 - 78.9 44.4 67.8
Five markers together 0.79 - 74.0 77.8 75.0
  1. AUC, area under the curve