Methylation levels of the

Table 1 Characteristics of the 42 AJCC stage IIIC melanoma patients

Variable	n. patients	%
Age, years
Median	54
Range	29-83
Gender
Male	27	64
Female	15	36
Localization of primary tumor
extremities	14	33
trunk	23	55
head & neck	3	7
NA*	2	5
Breslow thickness of primary tumor
≤2.0 mm	13	31
>2.0 mm	22	52
NA	7	17
Clark level of primary tumor
1- 3	12	29
4-5	24	57
NA	6	14
Ulceration of primary tumor
No	10	24
Yes	30	71
NA	2	5
N. lymph nodes involved
1	9	21
>1	33	79
LDH
Low_†	28	67
High	11	26
NA	3	7

*NA, not available
^† low LDH is established as LDH values ≤ 0.8 times the upper limit of normal; high LDH is defined as LDH values > 0.8 times the upper limit of normal

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