Figure 3
From: Ozone acting on human blood yields a hormetic dose-response relationship
The hypothetical inverted U-shaped curve describing an ideal dose-response relationship (panel A). The inverted U-shaped curve drawn on the basis of the therapeutic effect in PAD's patients by using an ozone concentration range between 15 and 80 μg/ml of gas per ml of blood. During a course of 15-20 sessions, the initial ozone concentration of 10 μg/ml has been slowly upgraded to the concentration of 80 μg/ml (panel B). The end-points that have been considered to determine the therapeutic effects are: claudication; ankle-brachial index; disappearance of pain; healing of skin ulcers.