Table 3 CYP450s responsible for M3 formation
From: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
| Â | CYP1A2 | CYP2D6 | CYP3A4 |
|---|---|---|---|
Km (μM) | 125.8 ± 3.57 | 12.0 ± 0.68 | 27.1 ± 1.03 |
Vmax (pmol/min/pmol P450) | 4.8 ± 0.54 | 2.9 ± 0.19 | 0.59 ± 0.012 |
Clint (μL/min/pmol P450) | 0.038 | 0.24 | 0.022 |
Nominal P450 Content in HLMs (pmol/mg) | 45 | 10 | 108 |
Adjusted Clint (μL/min/mg) | 1.71 | 2.4 | 2.376 |
Percentage Adjusted Clint (%) | 26.36 | 37.0 | 36.63 |