Figure 2

Repeated dose of rh-HGF induced an increase in urinary excretion of albumin and protein in rats. Rats were administered rh-HGF, 0.4 (A), 1.0 (B), and 4.0 mg/kg/day (C) (n = 4 for each), intravenously for 14 days, and urinary excretion of albumin and protein was measured before (day 1), during (days 7 and 14), and 7 and 14 days after HGF administration. Repeated doses of rh-HGF induced an increase in urinary albumin excretion in dose dependent manner. Urinary excretion of albumin was reversible even when dosing 4.0 mg/kg/day of rh-HGF (C), and preceded an increase in proteinuira in rats treated with 0.4 and 1.0 mg/kg of rh-HGF (A and B, respectively).