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Table 1 Relative changes in mRNA expression of vasoactive, inflammatory, anti-oxidative, and apoptotic mediators in renal parenchyma after IR injury

From: Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction

Variables Group 1 (n = 8) Group 2 (n = 8) Group 3 (n = 8) p-value
Endothelin-1 1.00* 2.38 ± 0.48† 1.81 ± 0.34‡ <0.02
Tumor necrosis factor-α 1.00* 2.29 ± 0.25† 1.80 ± 0.20‡ <0.004
Matrix metalloproteinase-9 1.00* 1.48 ± 0.14† 1.19 ± 0.09‡ <0.05
endothelial nitric oxide synthase 1.00* 0.62 ± 0.19† 0.89 ± 0.16‡ <0.05
Interleukin-10 1.00* 2.06 ± 0.37† 2.86 ± 0.50‡ <0.03
Adiponectin 1.00* 0.50 ± 0.13† 0.75 ± 0.13‡ <0.004
NQO1 1.00* 1.89 ± 0.62† 2.76 ± 0.88‡ <0.04
Glutathione reductase 1.00* 1.67 ± 0.25† 2.54 ± 0.64‡ <0.04
Glutathione peroxidase 1.00* 1.83 ± 0.39† 2.82 ± 0.98‡ <0.04
Bcl-2 1.00* 0.74 ± 0.09† 0.94 ± 0.10‡ <0.02
Caspase 3 1.00* 2.01 ± 0.20† 1.53 ± 0.14‡ <0.05
  1. Data are expressed as mean ± SD.
  2. NQO = NAD(P)H quinone oxidoreductase
  3. Group 1 = Normal control; Group 2 = Ischemia reperfusion; Group 3 = Ischemia reperfusion + adipose-derived mesenchymal stem cells
  4. Symbols (*, †, ‡) indicate significant difference (at 0.05 level) by Bonferroni multiple-comparison post hoc test.