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Table 2 The particle size and zeta potential of FA-PEAs:VHLpolyplexes

From: Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma

Weight Ratio

Particle size (nm) (±SD)

Zeta potential (mV) (±SD)

(Nanoparticles versus VHL plasmidsa)

FA-PEAs: VHL

PEI(2-kD): VHLc

FA-PEAs: VHL

PEI(2-kD): VHLc

5:1 b

277.5 ± 10.1

304.1 ± 5.7

4.4 ± 0.4

5.1 ± 0.3

10:1

238.8 ± 18.8

289.1 ± 8.9

7.1 ± 0.6

5.9 ± 0.3

15:1

182.4 ± 6.5

250.4 ± 4.6

11.4 ± 1.1

9.1 ± 0.2

20:1

165.4 ± 11.6

223.1 ± 12.5

15.6 ± 0.7

12.4 ± 0.9

25:1

143.5 ± 11.4

222.5 ± 9.3

22.4 ± 2.6

18.4 ± 0.5

30:1

140.3 ± 1.5

157.4 ± 5.1

31.6 ± 0.8

22.5 ± 0.7

  1. SD stands for standard deviation. All data were measured three times (n = 3).
  2. (a) The VHL plasmids were constant (2 μg), and the total volume of complexes was 1 ml.
  3. (b) The concentration of free FA-PEAs was 10 μg/ml.
  4. (c) The PEI (2-kD):VHL complexes were used as a control.
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Journal of Translational Medicine

ISSN: 1479-5876

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