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Table 1 Analyses of LLC tumor sections showing effects of different treatments on tumor infiltration by immune cells and apoptosis

From: Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma

Treatment group

Mean number/HPF ± SEM╪

 

Th cells (CD4)

Cytolytic T cells (CD8)

Apoptotic cells (TUNEL)

Proliferating cells (Ki-67)

AdCMV(-)

14.8 ± 2.8

20.6 ± 4.9

2.1 ± 1.2

437.4 ± 39.7

AdhTERTHRP

67.2 ± 7.7

79.1 ± 9.4

25.8 ± 3.3

471.5 ± 51.7

AdCMVmIL-12

109.6 ± 11.0

143.1 ± 38.7

14.4 ± 1.7

409.6 ± 36.1

Combination

139.1 ± 17.6

177.2 ± 12.6

40.2 ± 4.4

463.3 ± 55.4

P*

< 0.0001

< 0.0001

< 0.0001

> 0.05

  1. ╪After initial scanning under × 100 magnification, positive stained cells in 10 fields under × 400 (0.15 mm2) magnification were counted and the mean number/high-power field (HPF) was determined.
  2. *Statistical analyses were conducted with one-way ANOVA for all the parameters. P values less than 0.05 were considered statistically significant.
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Journal of Translational Medicine

ISSN: 1479-5876

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