Figure 3
In vivo evaluation of antitumor effect in a murine model of LLC. A, HRP expression in tumor tissues of various treatment groups was analyzed by western blot. B, IL-12 expression in tumor tissue lysates of different treatment groups was quantified by ELISA. N.D., no detection. C, tumor volumes were measured at the indicated time points after intratumoral injection with AdCMV(-), AdhTERTHRP, AdCMVmIL-12 alone or in combination. Each data point represented the mean tumor volume in that group. Error bars represented means ± SEM. B, long-term survival of animals after treatment with different strategies. (n = 5 per group).