Figure 2

Re-evaluation of SERPINE1 mRNA expression in fibroblasts under hypoxia (original Figure 4). Two different gene expression assays were applied to confirm SERPINE1 overexpression relative to POLR2A in fibroblasts cultured under hypoxia compared with fibroblasts cultured under normal oxygen conditions. Mean, minimum and maximum values are shown from three independent experiments reproduced in the cell line F-18 showing a much stronger induction than illustrated in the initial figure 4 (*** p < 0.001).