Treatment | Vehicle (N = 9) | CD continuous (N = 11) | HD intermittent (N = 11) | CD intermittent (N = 8) | HD continuous (N = 4) |
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Days to grow by 2 mm | 6.2 ± 1.9 | 9.2 ± 1.7 | 12.9 ± 3.3 | 7.1 ± 1.7 | 16.8 ± 3.9 |
- High dose intermittent therapy stabilized tumors longer as seen by the difference in the number of days for the tumors to increase by 2 mm in size. All arms are significantly different (P < 0.05) except the conventional dose (CD) continuous vs CD intermittent, the CD intermittent vs vehicle and the high dose (HD) intermittent vs HD continuous.