Figure 2

Anti-collagen II (CII) antibody levels after hAAT treatment. Anti-CII antibodies at day 35 and day 49 were tested by ELISA. Closed bars represent the average levels (n = 9, relative units, mean+SD) of antibodies in hAAT protein therapy treated group. Open bars represent the average levels (n = 7, relative units, mean+SD) of antibodies in saline injected group. (A) Levels of total Ig antibodies to bCII (total anti-bCII-Ig). (B) Levels of IgG2a anti-bCII (anti-bCII-IgG2a). (C) Levels of IgG1 anti-bCII (anti-bCII-IgG1). (D) Levels of total Ig antibodies to mCII (total anti-mCII-Ig). * p < 0.05 by Mann-Whitney U- test.