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Table 4 Multivariate analysis of OLP and HLA variables for clade B and C cohorts

From: Definition of the viral targets of protective HIV-1-specific T cell responses

OLP variables only (Lima, clade B)

OLP variables only (Durban, clade C)

 

change viral load (co-efficient) *

p-value

 

change viral load (co-efficient) *

p-value

Beneficial

  

Beneficial

  

OLP.6

-0.4591

0.0008

OLP.7

-0.6256

0

OLP.31

-1.4055

0.0002

OLP.21

-0.6663

0

OLP.171

-2.5981

0

OLP.22

-0.4926

0.0006

OLP.276

-1.127

0.0007

OLP.25

-0.2822

0.0002

   

OLP.27

-0.4719

0.0053

Non-beneficial

  

OLP.33

-0.3396

0.0024

OLP.76

0.2486

0.0067

OLP.398

-1.8179

0.0027

OLP.306

3.2968

0.0001

OLP.417

-1.6535

0.0008

OLP.411

1.3329

0.012

   
   

Non-beneficial

  
   

OLP.38

0.9045

0.0022

   

OLP.84

0.1947

0.0091

   

OLP.116

0.6156

0.0039

   

OLP.183

0.661

0.0013

   

OLP.224

0.2508

0.0036

   

OLP.265

0.5782

0

   

OLP.365

0.4911

0.0009

   

OLP.393

1.2624

0.0013

HLA variables only (Lima, clade B)

HLA variables only (Durban, clade C)

Non-beneficial

 

Beneficial

  

HLA-C0401

0.35652

0.00024

HLA-A74

-0.3553

0.0025

   

HLA-B13

-0.6443

0.0004

   

HLA-B57

-0.5195

0.0007

   

HLA-B81

-0.3619

0.0015

   

HLA-C12

-0.6544

0.0001

   

Non-beneficial

 
   

HLA.B.15

0.2506

0.0012

   

HLA.B.18

0.5521

0.0005

   

HLA.C.6

0.3958

0

HLA and OLP variables together (Lima)

HLA and OLP variables together (Durban)

Beneficial

  

Beneficial

  

OLP.6

-0.5792

0

OLP.6

-0.4798

0.0023

OLP.31

-1.1607

0.0005

OLP.7

-0.4528

0.0015

OLP.171

-2.7948

0

OLP.27

-0.4676

0.0049

OLP.276

-0.9609

0.0011

OLP.59

-0.4196

0.0115

   

OLP.417

-1.387

0.0041

Non-beneficial

 

Non-beneficial

 

OLP.2

0.3945

0.018

OLP.148

2.5215

0.0029

OLP.237

0.7211

0.0035

OLP.183

0.6108

0.0023

OLP.288

1.5537

0.0016

OLP.393

1.1442

0.0023

OLP.311

0.7197

0.0091

   

OLP.411

1.5306

0.0024

Beneficial

  
   

HLA-A74

-0.3744

0.0007

Beneficial

  

HLA-B57

-0.4887

0.0007

HLA-B1502

-1.4688

0.0164

HLA-B81

-0.3859

0.0004

   

HLA-C12

-0.6003

0.0002

Non-beneficial

  

Non-beneficial

  

HLA-B0801

0.66

0.0049

HLA-B15

0.2797

0.0001

HLA-C0401

0.2894

0.0006

HLA-B18

0.5316

0.0003

   

HLA-B49

0.9713

0.0007

  1. * negative co-efficient values indicate reduction in median viral loads