Table 4 Multivariate analysis of OLP and HLA variables for clade B and C cohorts
From: Definition of the viral targets of protective HIV-1-specific T cell responses
OLP variables only (Lima, clade B) | OLP variables only (Durban, clade C) | ||||
|---|---|---|---|---|---|
change viral load (co-efficient) * | p-value | change viral load (co-efficient) * | p-value | ||
Beneficial | Beneficial | ||||
OLP.6 | -0.4591 | 0.0008 | OLP.7 | -0.6256 | 0 |
OLP.31 | -1.4055 | 0.0002 | OLP.21 | -0.6663 | 0 |
OLP.171 | -2.5981 | 0 | OLP.22 | -0.4926 | 0.0006 |
OLP.276 | -1.127 | 0.0007 | OLP.25 | -0.2822 | 0.0002 |
OLP.27 | -0.4719 | 0.0053 | |||
Non-beneficial | OLP.33 | -0.3396 | 0.0024 | ||
OLP.76 | 0.2486 | 0.0067 | OLP.398 | -1.8179 | 0.0027 |
OLP.306 | 3.2968 | 0.0001 | OLP.417 | -1.6535 | 0.0008 |
OLP.411 | 1.3329 | 0.012 | |||
Non-beneficial | |||||
OLP.38 | 0.9045 | 0.0022 | |||
OLP.84 | 0.1947 | 0.0091 | |||
OLP.116 | 0.6156 | 0.0039 | |||
OLP.183 | 0.661 | 0.0013 | |||
OLP.224 | 0.2508 | 0.0036 | |||
OLP.265 | 0.5782 | 0 | |||
OLP.365 | 0.4911 | 0.0009 | |||
OLP.393 | 1.2624 | 0.0013 | |||
HLA variables only (Lima, clade B) | HLA variables only (Durban, clade C) | ||||
Non-beneficial | Beneficial | ||||
HLA-C0401 | 0.35652 | 0.00024 | HLA-A74 | -0.3553 | 0.0025 |
HLA-B13 | -0.6443 | 0.0004 | |||
HLA-B57 | -0.5195 | 0.0007 | |||
HLA-B81 | -0.3619 | 0.0015 | |||
HLA-C12 | -0.6544 | 0.0001 | |||
Non-beneficial | |||||
HLA.B.15 | 0.2506 | 0.0012 | |||
HLA.B.18 | 0.5521 | 0.0005 | |||
HLA.C.6 | 0.3958 | 0 | |||
HLA and OLP variables together (Lima) | HLA and OLP variables together (Durban) | ||||
Beneficial | Beneficial | ||||
OLP.6 | -0.5792 | 0 | OLP.6 | -0.4798 | 0.0023 |
OLP.31 | -1.1607 | 0.0005 | OLP.7 | -0.4528 | 0.0015 |
OLP.171 | -2.7948 | 0 | OLP.27 | -0.4676 | 0.0049 |
OLP.276 | -0.9609 | 0.0011 | OLP.59 | -0.4196 | 0.0115 |
OLP.417 | -1.387 | 0.0041 | |||
Non-beneficial | Non-beneficial | ||||
OLP.2 | 0.3945 | 0.018 | OLP.148 | 2.5215 | 0.0029 |
OLP.237 | 0.7211 | 0.0035 | OLP.183 | 0.6108 | 0.0023 |
OLP.288 | 1.5537 | 0.0016 | OLP.393 | 1.1442 | 0.0023 |
OLP.311 | 0.7197 | 0.0091 | |||
OLP.411 | 1.5306 | 0.0024 | Beneficial | ||
HLA-A74 | -0.3744 | 0.0007 | |||
Beneficial | HLA-B57 | -0.4887 | 0.0007 | ||
HLA-B1502 | -1.4688 | 0.0164 | HLA-B81 | -0.3859 | 0.0004 |
HLA-C12 | -0.6003 | 0.0002 | |||
Non-beneficial | Non-beneficial | ||||
HLA-B0801 | 0.66 | 0.0049 | HLA-B15 | 0.2797 | 0.0001 |
HLA-C0401 | 0.2894 | 0.0006 | HLA-B18 | 0.5316 | 0.0003 |
HLA-B49 | 0.9713 | 0.0007 | |||