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Table 4 Multivariate analysis of OLP and HLA variables for clade B and C cohorts

From: Definition of the viral targets of protective HIV-1-specific T cell responses

OLP variables only (Lima, clade B) OLP variables only (Durban, clade C)
  change viral load (co-efficient) * p-value   change viral load (co-efficient) * p-value
Beneficial    Beneficial   
OLP.6 -0.4591 0.0008 OLP.7 -0.6256 0
OLP.31 -1.4055 0.0002 OLP.21 -0.6663 0
OLP.171 -2.5981 0 OLP.22 -0.4926 0.0006
OLP.276 -1.127 0.0007 OLP.25 -0.2822 0.0002
    OLP.27 -0.4719 0.0053
Non-beneficial    OLP.33 -0.3396 0.0024
OLP.76 0.2486 0.0067 OLP.398 -1.8179 0.0027
OLP.306 3.2968 0.0001 OLP.417 -1.6535 0.0008
OLP.411 1.3329 0.012    
    Non-beneficial   
    OLP.38 0.9045 0.0022
    OLP.84 0.1947 0.0091
    OLP.116 0.6156 0.0039
    OLP.183 0.661 0.0013
    OLP.224 0.2508 0.0036
    OLP.265 0.5782 0
    OLP.365 0.4911 0.0009
    OLP.393 1.2624 0.0013
HLA variables only (Lima, clade B) HLA variables only (Durban, clade C)
Non-beneficial   Beneficial   
HLA-C0401 0.35652 0.00024 HLA-A74 -0.3553 0.0025
    HLA-B13 -0.6443 0.0004
    HLA-B57 -0.5195 0.0007
    HLA-B81 -0.3619 0.0015
    HLA-C12 -0.6544 0.0001
    Non-beneficial  
    HLA.B.15 0.2506 0.0012
    HLA.B.18 0.5521 0.0005
    HLA.C.6 0.3958 0
HLA and OLP variables together (Lima) HLA and OLP variables together (Durban)
Beneficial    Beneficial   
OLP.6 -0.5792 0 OLP.6 -0.4798 0.0023
OLP.31 -1.1607 0.0005 OLP.7 -0.4528 0.0015
OLP.171 -2.7948 0 OLP.27 -0.4676 0.0049
OLP.276 -0.9609 0.0011 OLP.59 -0.4196 0.0115
    OLP.417 -1.387 0.0041
Non-beneficial   Non-beneficial  
OLP.2 0.3945 0.018 OLP.148 2.5215 0.0029
OLP.237 0.7211 0.0035 OLP.183 0.6108 0.0023
OLP.288 1.5537 0.0016 OLP.393 1.1442 0.0023
OLP.311 0.7197 0.0091    
OLP.411 1.5306 0.0024 Beneficial   
    HLA-A74 -0.3744 0.0007
Beneficial    HLA-B57 -0.4887 0.0007
HLA-B1502 -1.4688 0.0164 HLA-B81 -0.3859 0.0004
    HLA-C12 -0.6003 0.0002
Non-beneficial    Non-beneficial   
HLA-B0801 0.66 0.0049 HLA-B15 0.2797 0.0001
HLA-C0401 0.2894 0.0006 HLA-B18 0.5316 0.0003
    HLA-B49 0.9713 0.0007
  1. * negative co-efficient values indicate reduction in median viral loads