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Table 3 Impact of HLA alleles on the statistical significance of observed PR values (clade C OLP)

From: Definition of the viral targets of protective HIV-1-specific T cell responses

A) Beneficial OLP (PR > 1)

  

OLP

Protein

PR

Removed HLA allele(s) abolishing statistical significance1

Alleles over-represented in the OLP responder group2

3

Gag

1.09

A30, B42, C17

A30, B08, A03, A74, C17, A43, B42, B07

6

Gag

1.22

B15

B49, B82, C14

7

Gag

1.25

-

B42, C17, B49, A30

22

Gag

1.18

B57, C07

B57, A74, B45, C07, C16, B13

25

Gag

1.06

A30, B15, C04, C07

B42, C17, B81, B39, A01, C12, C18, A30, B67

26

Gag

1.23

A02, A23, A68, B07, B14, B58, C07, C08

C03, B15, A68

27

Gag

1.16

B15, C07

B15, A68, C03, C08

29

Gag

1.07

A68, B15, B58, C02, C03, C06, C12

B35, B39, C12, B40, B07, C04

31

Gag

1.2

A02, A11, A23, A29, A32, A34, A68, B07,

B13, A29, C06, A11

   

B13, B15, B42, B44, B58, C04, C06, C07, C17

 

33

Gag

1.13

A02, A23, B44, B57, B58, C07

B58, B57, A02, C07, C03, A68

37

Gag

1.17

A30, B42, B58, C17

C18, B42, C17, A01, B81

39

Gag

1.34

A02, A03, A23, A29, A30, A68, A74, B08, B15,

A02

   

B18, B42, B45, B53, B57, B58, C02, C03, C06,

 
   

C07, C08, C16, C17

 

41

Gag

1.07

A23, C06

C03, B14, A68, C08, B15

42

Gag

1.09

A23, A30, B08, B15, B42, B53, B58, C03, C04, C07

B53, C03

55

Gag

1.19

A02, A24, A29, A30, B07, B15, B39, B42, B44,

B42, B08, C17

   

B58, C02, C06, C07, C17

 

59

Gag

1.16

A02, A30, B08, B42, B44, B58, C04, C07, C17

A02, B13, A29

60

Gag

1.21

A02, A30, B42, B58, C06, C07, C17

A02, B41, C07, C17

63

Gag

1.21

A02, A23, A29, A30, A68, B08, B15, B44, B58,

A23

   

C02, C03, C06, C07

 

181

Pol

1.19

A01, A23, A29, A30, A34, A68, A74, B14, B15,

B57, C18

   

B18, B35, B44, B45, B57, B58, C02, C03, C04,

 
   

C06, C07, C08, C16

 

199

Pol

1.2

A02, A03, A23, A24, A26, A30, A31, A34, A36, A66, A68,

B53, A23, C04

   

A80, B08, B13, B15, B18, B35, B40, B41, B42, B44, B45,

 
   

B49, B50, B51, B53, B57, B58, B81, C01, C02, C03, C04,

 
   

C05, C06, C07, C08, C15, C16, C17

 

216

Pol

1.09

A02, A30, B58, C07, C17

B53, B58, C07, B57

417

Vif

1.5

A03, A23, A30, A34, A36, A68, B08, B14, B15,

B14, C08, A36

   

B44, B53, B58, C03, C04, C06, C08

 

B) Non-beneficial OLP (PR < 1)

    

116

Tat

0.91

A02, A34, B15, C04

B15, C02

178

Pol

0.84

A03, A68, B15, B58, C04, C06, C07

A68, C06, B58, B82, A03

190

Pol

0.92

A03, A30, A66, B18, B42, B45, B58, C06, C07

A02, B18, B35, C05, C16, B45, A80, C12, B67, B39

239

Pol

0.82

-

C05, A03

253

Pol

0.92

A03, A68, B15, B39, B42, B44, B58, C02, C04, C06, C08,

A68, C03, B15, B07, C15, B41

   

C17, C18

 

265

Pol

0.94

A02, A03, A23, A24, A26, A29, A30, A31, A33,

B15, C02, A43, A74

   

A34, A66, A68, B07, B08, B14, B15, B27, B40, B41, B42,

 
   

B44, B53, B54, B55, B57, B81, C01, C02, C04, C06, C07,

 
   

C12, C17, C18

 

283

Vpr

0.93

A02, A03, A23, A30, A66, A68, A74, B07, B14, B18, B39,

A68, C03, B07, C17, B41

   

B41, B42, B45, B57, C02, C04, C07, C08, C15, C17

 

284

Vpr

0.92

A03, A23, A30, A66, A68, A74, B07, B14, B18, B39, B42,

A68, C03

   

B45, B57, C07, C08, C15, C17

 

312

Env

0.84

-

B08, C07

365

Env

0.88

B58, C06

C06, B58, A43, B45, C16, A66

393

Env

0.78

A30, B58, C06

A31, C06, B45

  1. 1) in italics HLA alleles that do not emerge from the Hepitope analysis 2) cut-off in Hepitope analyses for p < 0.05, alleles sorted according to strength of association
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Journal of Translational Medicine

ISSN: 1479-5876

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