Table 2 Beneficial and non-beneficial OLP identified in Durban clade C cohort (q < 0.2)
From: Definition of the viral targets of protective HIV-1-specific T cell responses
OLP # | Protein | Sub-unit | OLP clade C consensus sequence | Median viral load in OLP responders | Median viral load in OLP non-responders | Protective Ratio (PR)* | p-value | Q-value |
|---|---|---|---|---|---|---|---|---|
3 | Gag | p17 | EKIRLRPGGKKHYMLKHL | 18,700 | 45,100 | 1.09 | 0.0002 | 0.0006 |
6 | Gag | p17 | ASRELERFALNPGLL | 6,570 | 44,100 | 1.22 | 0.0000 | 0.0000 |
7 | Gag | p17 | ERFALNPGLLETSEGCK | 5,270 | 43,900 | 1.25 | 0.0000 | 0.0000 |
22 | Gag | p24 | WVKVIEEKAFSPEVIPMF | 8,360 | 42,850 | 1.18 | 0.0000 | 0.0000 |
25 | Gag | p24 | GATPQDLNTMLNTVGGH | 24,450 | 45,200 | 1.06 | 0.0021 | 0.0263 |
26 | Gag | p24 | NTMLNTVGGHQAAMQMLK | 5,310 | 39,600 | 1.23 | 0.0061 | 0.0766 |
27 | Gag | p24 | GGHQAAMQMLKDTINEEA | 9,715 | 42,100 | 1.16 | 0.0015 | 0.0170 |
29 | Gag | p24 | AAEWDRLHPVHAGPIA | 19,700 | 40,900 | 1.07 | 0.0045 | 0.0544 |
31 | Gag | p24 | IAPGQMREPRGSDIA | 6,480 | 38,950 | 1.20 | 0.0146 | 0.1478 |
33 | Gag | p24 | SDIAGTTSTLQEQIAWM | 11,650 | 40,900 | 1.13 | 0.0025 | 0.0318 |
37 | Gag | p24 | WIILGLNKIVRMYSPVSI | 9,360 | 44,100 | 1.17 | 0.0004 | 0.0018 |
39 | Gag | p24 | SILDIKQGPKEPFRDYV | 2,630 | 38,250 | 1.34 | 0.0182 | 0.1838 |
41 | Gag | p24 | YVDRFFKTLRAEQATQDV | 22,150 | 44,100 | 1.07 | 0.0020 | 0.0263 |
42 | Gag | p24 | LRAEQATQDVKNWMTDTL | 16,480 | 40,900 | 1.09 | 0.0078 | 0.0935 |
55 | Gag | p15 | HIARNCRAPRKKGCWK | 7,550 | 39,700 | 1.19 | 0.0092 | 0.1047 |
59 | Gag | p15 | RQANFLGKIWPSHKGR | 9,840 | 42,200 | 1.16 | 0.0046 | 0.0539 |
60 | Gag | p15 | GKIWPSHKGRPGNFLQSR | 6,130 | 39,700 | 1.21 | 0.0066 | 0.0799 |
63 | Gag | p15 | TAPPAESFRFEETTPAPK | 6,040 | 38,950 | 1.21 | 0.0093 | 0.1020 |
116 | Tat | Tat | TKGLGISYGRKKRRQRRS | 109,000 | 36,700 | 0.91 | 0.0033 | 0.0410 |
178 | Pol | RT | FWEVQLGIPHPAGLKKKK | 258,000 | 37,300 | 0.84 | 0.0033 | 0.0384 |
181 | Pol | RT | LDVGDAYFSVPLDEDFRK | 7,100 | 38,950 | 1.19 | 0.0186 | 0.1832 |
190 | Pol | RT | RAQNPEIVIYQYMDDLYV | 84,900 | 34,700 | 0.92 | 0.0043 | 0.0555 |
199 | Pol | RT | TVQPIQLPEKDSWTVNDI | 6,700 | 38,300 | 1.20 | 0.0198 | 0.1926 |
216 | Pol | RT | QKIAMESIVIWGKTPKFR | 18,150 | 43,000 | 1.09 | 0.0026 | 0.0317 |
239 | Pol | RT | QVDKLVSSGIRKVLFL | 373,200 | 37,700 | 0.82 | 0.0205 | 0.1937 |
253 | Pol | Int | PAETGQETAYFILKLAGR | 92,800 | 35,400 | 0.92 | 0.0082 | 0.0954 |
265 | Pol | Int | AVFIHNFKRKGGIGGYSA | 63,650 | 33,800 | 0.94 | 0.0178 | 0.1826 |
283 | Vpr | - | GLGQYIYETYGDTWTGV | 78,000 | 35,600 | 0.93 | 0.0126 | 0.1302 |
284 | Vpr | - | ETYGDTWTGVEALIRIL | 85,050 | 35,200 | 0.92 | 0.0099 | 0.1034 |
312 | Env | Gp120 | YALFYRLDIVPLNENNSSEY | 270,000 | 37,700 | 0.84 | 0.0208 | 0.1915 |
365 | Env | Gp41 | GIKQLQTRVLAIERYLK | 151,000 | 34,700 | 0.88 | 0.0001 | 0.0002 |
393 | Env | Gp41 | LLGRSSLRGLQRGWEALKYL | 750,000 | 37,450 | 0.78 | 0.0007 | 0.0041 |
417 | Vif | - | CFADSAIRKAILGHIV | 1,110 | 38,200 | 1.50 | 0.0178 | 0.1891 |