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Table 2 Beneficial and non-beneficial OLP identified in Durban clade C cohort (q < 0.2)

From: Definition of the viral targets of protective HIV-1-specific T cell responses

OLP # Protein Sub-unit OLP clade C
consensus
sequence
Median viral
load in OLP
responders
Median viral
load in OLP
non-responders
Protective Ratio
(PR)*
p-value Q-value
3 Gag p17 EKIRLRPGGKKHYMLKHL 18,700 45,100 1.09 0.0002 0.0006
6 Gag p17 ASRELERFALNPGLL 6,570 44,100 1.22 0.0000 0.0000
7 Gag p17 ERFALNPGLLETSEGCK 5,270 43,900 1.25 0.0000 0.0000
22 Gag p24 WVKVIEEKAFSPEVIPMF 8,360 42,850 1.18 0.0000 0.0000
25 Gag p24 GATPQDLNTMLNTVGGH 24,450 45,200 1.06 0.0021 0.0263
26 Gag p24 NTMLNTVGGHQAAMQMLK 5,310 39,600 1.23 0.0061 0.0766
27 Gag p24 GGHQAAMQMLKDTINEEA 9,715 42,100 1.16 0.0015 0.0170
29 Gag p24 AAEWDRLHPVHAGPIA 19,700 40,900 1.07 0.0045 0.0544
31 Gag p24 IAPGQMREPRGSDIA 6,480 38,950 1.20 0.0146 0.1478
33 Gag p24 SDIAGTTSTLQEQIAWM 11,650 40,900 1.13 0.0025 0.0318
37 Gag p24 WIILGLNKIVRMYSPVSI 9,360 44,100 1.17 0.0004 0.0018
39 Gag p24 SILDIKQGPKEPFRDYV 2,630 38,250 1.34 0.0182 0.1838
41 Gag p24 YVDRFFKTLRAEQATQDV 22,150 44,100 1.07 0.0020 0.0263
42 Gag p24 LRAEQATQDVKNWMTDTL 16,480 40,900 1.09 0.0078 0.0935
55 Gag p15 HIARNCRAPRKKGCWK 7,550 39,700 1.19 0.0092 0.1047
59 Gag p15 RQANFLGKIWPSHKGR 9,840 42,200 1.16 0.0046 0.0539
60 Gag p15 GKIWPSHKGRPGNFLQSR 6,130 39,700 1.21 0.0066 0.0799
63 Gag p15 TAPPAESFRFEETTPAPK 6,040 38,950 1.21 0.0093 0.1020
116 Tat Tat TKGLGISYGRKKRRQRRS 109,000 36,700 0.91 0.0033 0.0410
178 Pol RT FWEVQLGIPHPAGLKKKK 258,000 37,300 0.84 0.0033 0.0384
181 Pol RT LDVGDAYFSVPLDEDFRK 7,100 38,950 1.19 0.0186 0.1832
190 Pol RT RAQNPEIVIYQYMDDLYV 84,900 34,700 0.92 0.0043 0.0555
199 Pol RT TVQPIQLPEKDSWTVNDI 6,700 38,300 1.20 0.0198 0.1926
216 Pol RT QKIAMESIVIWGKTPKFR 18,150 43,000 1.09 0.0026 0.0317
239 Pol RT QVDKLVSSGIRKVLFL 373,200 37,700 0.82 0.0205 0.1937
253 Pol Int PAETGQETAYFILKLAGR 92,800 35,400 0.92 0.0082 0.0954
265 Pol Int AVFIHNFKRKGGIGGYSA 63,650 33,800 0.94 0.0178 0.1826
283 Vpr - GLGQYIYETYGDTWTGV 78,000 35,600 0.93 0.0126 0.1302
284 Vpr - ETYGDTWTGVEALIRIL 85,050 35,200 0.92 0.0099 0.1034
312 Env Gp120 YALFYRLDIVPLNENNSSEY 270,000 37,700 0.84 0.0208 0.1915
365 Env Gp41 GIKQLQTRVLAIERYLK 151,000 34,700 0.88 0.0001 0.0002
393 Env Gp41 LLGRSSLRGLQRGWEALKYL 750,000 37,450 0.78 0.0007 0.0041
417 Vif - CFADSAIRKAILGHIV 1,110 38,200 1.50 0.0178 0.1891
  1. * PR values in bold indicate PR > 1, i.e. OLP-responses seen more frequently in individuals with reduced viral loads