Figure 3

Characterization of Tcregs and Tc17 cells in NPC. (A) Expression of phenotypic markers, including CD45RO, CD45RA, CCR6, CCR7, CTLA4, and GITR, on Tcregs and Tc17 cells from PBMCs and TILs of one representative NPC patient. (B and C) Cytokine profiles of Tcregs (B) and Tc17 cells (C). Tcregs expressed high levels of IL-10 but low levels of IL-2, TNFα, IL-17, and IFNγ, except Tcregs from TILs, which expressed significantly higher levels of IFNγ compared with NPC PBMCs. Tc17 cells expressed high levels of TNFα, an intermediate level of IL-10, and low levels of IL-2 and IFNγ, except for cells from TILs, which also expressed significantly higher levels of IFNγ compared with NPC PBMCs. Data are from five patients with NPC and five healthy donors. *P < 0.005.