Time-dependent effects of PF-03882845 on plasma aldosterone AUC. PF-03882845 resulted in a time-dependent increase in plasma aldosterone AUC corrected to vehicle in Spontaneously Hypertensive Rats (SHR). Statistical analysis indicated an overall significant effect of time (P = 0.0454 by one-way ANOVA). There was no significance between any two groups when analyzed with Tukey's Multiple Comparison Test. Data are shown as mean + SEM.