Figure 2From: The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonismEffects of eplerenone on urinary log10 Na+/K+ in humans. Eplerenone elicited a dose-dependent increase in urinary Na+/K+ in humans. Points represent observed effect in individual subjects. The solid line represents the predicted time course of the effect derived from the indirect response model described in the methods section.Back to article page