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Figure 1 | Journal of Translational Medicine

Figure 1

From: The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

Figure 1

Effect of eplerenone and PF-03882845 on urinary Na+/K+ in rats. Eplerenone (A) and PF-03882845 (B) elicited a dose-dependent increase in urinary Na+/K+ ratio in Sprague-Dawley rats following administration of single doses. Points represent observed effects in individual rats. The solid line represents the predicted time course of the effect derived from the indirect response model described in the methods section.

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