Table 1 Clinical, pathological and molecular characterists of GISTs
From: Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy
Case | Anatomical location | Molecular Status | Clinical response1 | Pathological response2 | Tumor Sample | Size3 (cm) |
|---|---|---|---|---|---|---|
GIST 1 | Stomach | KIT exon 11 Del 558-563 | Non treated | Non treated | Primary | >10 |
GIST 2 | Ileum | KIT exon 11 L576P | Stable disease | >90% of viable cells-non responder | Recurrence | 2-5 |
GIST 3 | Esophagus | KIT exon 11 Del 554-558 | In response | 10% of viable cells-high responder | Primary | 5-10 |
GIST 4 | Stomach | KIT exon 11 Del 557-558 | In response | 10% of viable cells-high responder | Primary | >10 |
GIST 5 | Stomach | KIT exon 11 V559D | In response | 10% of viable cells-high responder | Primary | >10 |
GIST6 | Stomach | PDGRF alpha D842V | Unresponsive | 25% of viable cells-high responder | Recurrence | < 2 |
GIST7 | Ileum | KIT exon 9 Dup 502-503 | Unresponsive | >90% of viable cells-non responder | Liver metastasis | 5-10 |
GIST8 | Pelvis | KIT exon 11 Del 558-560 and V557C | Unresponsive | >5% of viable cells-high responder | Liver metastasis | 2-5 |
GIST9 | Stomach | PDGFR alpha D842V | Unresponsive | >90% of viable cells-non responder | Primary | 2-5 |
GIST10 | Stomach | KIT wt | Unresponsive | >90% of viable cells-non responder | Primary | >10 |
GIST11 | Stomach | KIT Dup P577-K581 | Unresponsive | >90% of viable cells-non responder | Primary | 5-10 |
GIST12 | Omentum | KIT Dup A502-Y503 and N822K | Unresponsive | >90% of viable cells-non responder | Metastasis | < 2 |
GIST13 | Intestin | KIT K642E and N822K | Unresponsive | >90% of viable cells-non responder | Primary | >10 |
GIST14 | Intestin | KIT Del M552-Y553 and E554K | In response | 50-90% of viable cells-moderate responder | Recurrence | 5-10 |
GIST15 | Stomach | KIT K642E | In response | 50-90% of viable cells-moderate responder | Metastasis | 5-10 |
GIST16 | Intestin | KIT Dup 502-503 | In response | 50-90% of viable cells-moderate responder | Primary | < 2 |