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Table 1 Clinical, pathological and molecular characterists of GISTs

From: Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy

Case Anatomical location Molecular Status Clinical response1 Pathological response2 Tumor Sample Size3 (cm)
GIST 1 Stomach KIT exon 11 Del 558-563 Non treated Non treated Primary >10
GIST 2 Ileum KIT exon 11 L576P Stable disease >90% of viable cells-non responder Recurrence 2-5
GIST 3 Esophagus KIT exon 11 Del 554-558 In response 10% of viable cells-high responder Primary 5-10
GIST 4 Stomach KIT exon 11 Del 557-558 In response 10% of viable cells-high responder Primary >10
GIST 5 Stomach KIT exon 11 V559D In response 10% of viable cells-high responder Primary >10
GIST6 Stomach PDGRF alpha D842V Unresponsive 25% of viable cells-high responder Recurrence < 2
GIST7 Ileum KIT exon 9 Dup 502-503 Unresponsive >90% of viable cells-non responder Liver metastasis 5-10
GIST8 Pelvis KIT exon 11 Del 558-560 and V557C Unresponsive >5% of viable cells-high responder Liver metastasis 2-5
GIST9 Stomach PDGFR alpha D842V Unresponsive >90% of viable cells-non responder Primary 2-5
GIST10 Stomach KIT wt Unresponsive >90% of viable cells-non responder Primary >10
GIST11 Stomach KIT Dup P577-K581 Unresponsive >90% of viable cells-non responder Primary 5-10
GIST12 Omentum KIT Dup A502-Y503 and N822K Unresponsive >90% of viable cells-non responder Metastasis < 2
GIST13 Intestin KIT K642E and N822K Unresponsive >90% of viable cells-non responder Primary >10
GIST14 Intestin KIT Del M552-Y553 and E554K In response 50-90% of viable cells-moderate responder Recurrence 5-10
GIST15 Stomach KIT K642E In response 50-90% of viable cells-moderate responder Metastasis 5-10
GIST16 Intestin KIT Dup 502-503 In response 50-90% of viable cells-moderate responder Primary < 2
  1. 1 Evaluated on the frozen material used for the proteomic/biochemical analyses [16].
  2. 2 According to refs 17 and 18.
  3. 3 The size of the tumor was measured considering the maximum diameter.