Figure 1
( A and B ) Bone marrow micrometastases (arrows) surrounded by red hematopoietic tissue in vertebral bodies on the 10th day after B16 melanoma cell injection (Scale bars: 250 μm in A and 50 μm in B). ( C ) Gum pigmentation due to mandible metastasis and ( D ) skull of a mouse showing a melanotic nodule (arrows) in flat bones on the 15th day following left cardiac ventricle injection of B16M cells (Scale bars: 4 mm); ( E ) Compression of the spinal cord due to metastases of B16M cells to lumbar vertebral bodies (arrows) was observed (Scale bar: 2 mm).