Table 2 Associations between TLR4 Thr399Ile SNP genotype and clinicopathological variables
Total | Thr399Thr | Thr399Ile | P | |
|---|---|---|---|---|
n (%) | 62 | 51 (82.3) | 11 (17.7) | |
Laryngeal SCC; n (%) | 62 | 51 (82.3) | 11 (17.7) | |
Mean age ± SD [years] | 60 ± 10 | 61 ± 10 | 57 ± 7 | 0.13 |
Median follow up [months] (range)# | 52 (0-129) | 55 (0-129) | 43 (9-98) | 0.38 |
Sex (male/female); n | 55/7 | 44/7 | 11/0 | 0.33 |
Smoking; n (%) | 54 (87.1) | 43 (84.3) | 11 (100) | 0.33 |
Mean pack years ± SD | 50 ± 20.3 | 48.9 ± 20.3 | 54.1 ± 21.1 | 0.53 |
Primary therapy | 0.02 | |||
Surgery alone; n (%) | 34 | 31 (60.8) | 3 (27.3) | |
Surgery + RCT§; n (%) | 23 | 18 (35.3) | 5 (45.4) | |
Primary RCT§; n (%) | 5 | 2 (3.9) | 3 (27.3) | |
AJCC stage | < 0.01 | |||
I; n (%) | 11 | 10 (19.6) | 1 (9.1) | |
II; n (%) | 16 | 14 (27.5) | 2 (18.2) | |
III; n (%) | 9 | 3 (5.9) | 6 (54.5) | |
IVA; n (%) | 25 | 23 (45.1) | 2 (18.2) | |
IVB; n (%) | 0 | 0 (0.0) | 0 (0.0) | |
IVC; n (%) | 1 | 1 (1.9) | 0 (0.0) | |
Grade | 0.86 | |||
1; n(%) | 4 | 4 (7.8) | 0 (0.0) | |
2; n(%) | 43 | 34 (66.6) | 9 (81.8) | |
3-4; n(%) | 11 | 9 (17.6) | 2 (18.2) |