Figure 4From: Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancerEffects of NVP-BEZ235 on renal cell carcinoma cells in vitro. Targets of NVP-BEZ235, p-P70S6K, p-Akt and p-S6 were decreased in Caki-1, 769-P, A498 and 786-0 cells with exposure to the drug. Cells were exposed to 0.1 and 1.0 μM NVP-BEZ235, or DMSO (vehicle) for 4 and 24 hours. β-actin is shown as a loading control.Back to article page