Kinetics of anti-Aβ (A) and anti-WSN-WT antibody responses (B) in mice immunized with 50 μg/mouse of WSN-Aβ
and WSN-WT viruses. Concentration of anti-Aβ antibodies and half-maximal titers (HMAT) of anti-WSN-WT antibodies were analyzed in individual mice. HMAT was determined in the sera of individual mice by dividing the highest OD450 value in the dilution range of each sample by two. Initial dilution of sera in these experiments was 1:500 and they were serially diluted up to 1:500000. Error bars indicate the average ± s.d. n = 16 and n = 8 in groups immunized with WSN-Aβ1-10 and WSN-WT viruses respectively (**P < 0.01, ***P < 0.001).