Figure 6

Kinetics of anti-Aβ (A) and anti-WSN-WT antibody responses (B) in mice immunized with 50 μg/mouse of WSN-Aβ _1-10 and WSN-WT viruses. Concentration of anti-Aβ antibodies and half-maximal titers (HMAT) of anti-WSN-WT antibodies were analyzed in individual mice. HMAT was determined in the sera of individual mice by dividing the highest OD₄₅₀ value in the dilution range of each sample by two. Initial dilution of sera in these experiments was 1:500 and they were serially diluted up to 1:500000. Error bars indicate the average ± s.d. n = 16 and n = 8 in groups immunized with WSN-Aβ_1-10 and WSN-WT viruses respectively (**P < 0.01, ***P < 0.001).