Table 3 IHC Expression of Her2 and He3 in Primary Tumors, Paired Metastatic Carcinomas and Recurrent HNSCC
| Â | Primary (n = 387) | Metastatic (n = 20) | Recurrent (n = 17) | P value |
|---|---|---|---|---|
Her2 (membranous) | Â | Â | Â | Â |
   Negative | 283 (73.1) | 11 (55.0) | 10 (58.8) | 0.104 |
   Positive | 104 (26.9) | 9 (45.0) | 7 (41.2) |  |
Her3 (membranous) | Â | Â | Â | Â |
   Negative | 353 (91.2) | 14 (70.0) | 17 (100) | 0.003 |
   Positive | 34 (8.8) | 6 (30.0) | 0 (0) |  |
Her3 (cytoplasmic) | Â | Â | Â | Â |
   Negative | 87 (22.5) | 6 (30.0) | 3 (17.6) | 0.649 |
   Positive | 300 (77.5) | 14 (70.0) | 14 (82.4) |  |